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Homatropine Bromide
CAS No. 51-56-9
Homatropine Bromide( —— )
Catalog No. M14794 CAS No. 51-56-9
Homatropine Bromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameHomatropine Bromide
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NoteResearch use only, not for human use.
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Brief DescriptionHomatropine Bromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors.
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DescriptionHomatropine Bromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors.
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In VitroHomatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs, and produces a dose ratio of only 95.0 when combined with Hexamethonium Bromide (HY-B0569) in atrium from guinea-pigs. Homatropine has affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses.
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In VivoHomatropine methylbromide (9 mm x 5 mm conical suppository) causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure in rats. Animal Model:Male albino ratsDosage:9 mm x 5 mm conical suppository Administration:By suppository Result:Blocked cardiovascular responses to vagal stimulation and acetylcholine; 10-20 min after insertion of the suppository the effects of vagal stimulation over a range of 2-16 Hz, 5 V, on pulse rate was virtually abolished and remained unchanged at 45-60 min.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAChR
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RecptormAChR (SHR-E)| mAChR (WKY-E)
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number51-56-9
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Formula Weight356.26
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Molecular FormulaC16H22BrNO3
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Purity>98% (HPLC)
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SolubilityWater: 71 mg/mL (199.29 mM); DMSO: 71 mg/mL (199.29 mM)
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SMILESCN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sim MK, et al. Clin Exp Hypertens, 1993, 15(2), 409-42
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